SB 414240 [Ligand Id: 5769] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL295770 (SB-414240) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Binding affinity towards human mu-opioid receptors in CHO (Chinese hamster ovary) cell lines | B | 5.7 | pKi | >=2000 | nM | Ki | J Med Chem (2001) 44: 1675-1689 [PMID:11356103] |
| NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] | ||||||||
| GtoPdb | - | - | 9 | pKi | 1 | nM | Ki | J Med Chem (2001) 44: 1675-89 [PMID:11356103] |
| ChEMBL | Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2001) 44: 1675-1689 [PMID:11356103] |
| NK3 receptor/Neurokinin 3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4429] [GtoPdb: 362] [UniProtKB: P29371] | ||||||||
| ChEMBL | Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranes | B | 6.71 | pKi | 193 | nM | Ki | J Med Chem (2001) 44: 1675-1689 [PMID:11356103] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
