Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL222301 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] | ||||||||
ChEMBL | Displacement of [3H]SCH-23390 from rat striatum dopamine D1 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | Displacement of [3H]spiperone from rat striatum dopamine D2 receptor | B | 5.89 | pKi | 1285 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
ChEMBL | Displacement of [3H]7OH-DPAT from rat olfactory tubercle dopamine D3 receptor | B | 5.31 | pKi | 4900 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] | ||||||||
ChEMBL | Displacement of [3H]WIN-35428 from rat striatum DAT | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
ChEMBL | Displacement of [3H]CGP-39653 from rat cortex NMDA receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
H1 receptor/Histamine H1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4701] [GtoPdb: 262] [UniProtKB: P31390] | ||||||||
ChEMBL | Displacement of [3H]pyrilamine from rat cortex histamine H1 receptor | B | 5.85 | pKi | 1422 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
ChEMBL | Displacement of [3H]ketanserin from rat cortex 5HT2A receptor | B | 5.5 | pKi | 3149 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Displacement of [3H]mesulergine from guinea pig cortex 5HT2C receptor | B | 5.36 | pKi | 4357 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
5-HT3A/Serotonin 3a (5-HT3a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2411] [GtoPdb: 373] [UniProtKB: P35563] | ||||||||
ChEMBL | Displacement of [3H]LY278584 from rat cortex 5HT3 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528] | ||||||||
ChEMBL | Displacement of [3H]GR-13808 from guinea pig cortex 5HT4 receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3372] [GtoPdb: 11] [UniProtKB: P31388] | ||||||||
ChEMBL | Displacement of [3H]5HT from rat cloned 5HT6 receptor expressed in HEK293 cells | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
ChEMBL | Displacement of [3H]citalopram from rat cortex SERT | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492] | ||||||||
ChEMBL | Displacement of [3H](+)-pentazocine from guinea pig sigma1 opioid receptor by liquid scintillation counting | B | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (2010) 53: 5881-5885 [PMID:20684615] |
ChEMBL | Displacement of [3H](+)-pentazocine from guinea pig brain sigma 1 receptor | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2007) 50: 951-961 [PMID:17328523] |
sigma non-opioid intracellular receptor 1 in Human [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
GtoPdb | - | - | 8.8 | pKi | - | - | - | J Med Chem (2007) 50: 951-61 [PMID:17328523] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]