D1 receptor

Nomenclature: D1 receptor

Family: Dopamine receptors

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 446 5q35.1 DRD1 dopamine receptor D1 18,51,61
Mouse 7 446 13 B1 Drd1a dopamine receptor D1A 49
Rat 7 446 17p14 Drd1 dopamine receptor D1 36,61
Previous and Unofficial Names
D1A
DADR
DRD1A
Gpcr15
D1A
Drd-1
Drd1
D(1A) dopamine receptor
Dopamine-1A receptor
dopamine D1 receptor
dopamine receptor 1A
dopamine receptor D1A
D1 receptor
C030036C15Rik
Drd1a
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GPCRDB
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
PharmGKB Gene
PhosphoSitePlus
Protein Ontology (PRO)
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Natural/Endogenous Ligands
dopamine
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
SKF-81297 Rn Full agonist 8.7 pKi 5
pKi 8.7 [5]
SKF-75670 Rn Full agonist 8.7 pKi 5
pKi 8.7 [5]
(+)-SKF-82526 Hs Full agonist 7.55 pKi 50
pKi 7.55 (Ki 2.8x10-8 M) [50]
NPA Hs Full agonist 7.4 pKi 50
pKi 7.4 [50]
lisuride Hs Partial agonist 7.2 pKi 34
pKi 7.2 [34]
fenoldopam Hs Full agonist 6.5 – 7.9 pKi 53
pKi 6.5 – 7.9 [53]
cabergoline Hs Full agonist 6.7 pKi 34
pKi 6.7 [34]
SKF-38393 Hs Partial agonist 6.2 – 6.8 pKi 50,53
pKi 6.2 – 6.8 [50,53]
pergolide Hs Full agonist 5.9 – 6.5 pKi 34,50
pKi 5.9 – 6.5 [34,50]
SKF-76783 Hs Full agonist 6.2 pKi 50
pKi 6.2 [50]
bromocriptine Hs Partial agonist 6.2 pKi 34,50
pKi 6.2 [34,50]
(+)-ADTN Hs Full agonist 5.3 – 6.4 pKi 34,50
pKi 5.3 – 6.4 [34,50]
apomorphine Hs Full agonist 5.3 – 6.2 pKi 50,53
pKi 5.3 – 6.2 [50,53]
(-)-SKF-82526 Hs Partial agonist 5.74 pKi 50
pKi 5.74 (Ki 1.818x10-6 M) [50]
rotigotine Hs Full agonist 5.6 pKi 50
pKi 5.6 [50]
5-HT Hs Partial agonist 5.0 pKi 50
pKi 5.0 [50]
dopamine Hs Full agonist 4.3 – 5.6 pKi 50,53
pKi 4.3 – 5.6 [50,53]
noradrenaline Hs Full agonist 4.3 pKi 50
pKi 4.3 [50]
A68930 Hs Agonist 6.82 pEC50 37
pEC50 6.82 (EC50 1.511x10-7 M) [37]
View species-specific agonist tables
Agonist Comments
Reference [5] uses rat striatal homogenate to obtain pKi values.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
[125I]SCH23982 Hs Antagonist 9.5 pKd 18
pKd 9.5 (Kd 3.5x10-10 M) [18]
[3H]SCH-23390 Hs Antagonist 9.5 pKd 61
pKd 9.5 (Kd 3x10-10 M) [61]
SKF-83556 Hs Antagonist 9.5 pKi 50
pKi 9.5 [50]
SCH-23390 Hs Antagonist 7.4 – 9.5 pKi 50,53
pKi 7.4 – 9.5 [50,53]
ecopipam Hs Antagonist 8.3 pKi 54
pKi 8.3 (Ki 5x10-9 M) [54]
fluphenazine Hs Antagonist 7.7 pKi 50
pKi 7.7 [50]
cis-flupentixol Hs Antagonist 7.0 – 8.4 pKi 50,53
pKi 7.0 – 8.4 [50,53]
Description: Note that this assay uses the cis form of the compound, whereas the approved drug is a racemic mixture of cis and trans molecules.
haloperidol Hs Antagonist 7.6 pKi 50
pKi 7.6 [50]
(+)-butaclamol Hs Antagonist 6.5 – 8.5 pKi 50,53
pKi 6.5 – 8.5 [50,53]
prochlorperazine Hs Antagonist 7.11 pKi 9
pKi 7.11 (Ki 7.8x10-8 M) [9]
chlorpromazine Hs Antagonist 7.1 pKi 50
pKi 7.1 [50]
thioridazine Hs Antagonist 7.0 pKi 50
pKi 7.0 [50]
clozapine Hs Antagonist 6.9 pKi 50
pKi 6.9 [50]
spiperone Hs Antagonist 6.7 pKi 50
pKi 6.7 [50]
ketanserin Hs Antagonist 6.7 pKi 50
pKi 6.7 [50]
Primary Transduction Mechanisms
Transducer Effector/Response
Gs family Adenylate cyclase stimulation
References:  13
Secondary Transduction Mechanisms
Transducer Effector/Response
Gs family Calcium channel
Comments: 
Extracellular signal-regulated kinases [40,56]
Mammalian target of rapamycin complex 1 (mTORC1) [43-44]
Phospholipase C β - transducer undetermined [33,55]
References:  7,24
Tissue Distribution
Seminal vesicles.
Species:  Human
Technique:  RT-PCR and Western blot.
References:  26
Adrenal cortex.
Species:  Human
Technique:  Radioligand binding.
References:  1
Heart, kidney.
Species:  Human
Technique:  Western Blot and Immunohistochemistry.
References:  41
Retina.
Species:  Rat
Technique:  Immunohistochemistry.
References:  57
Seminal vesicles.
Species:  Rat
Technique:  RT-PCR and Western blot.
References:  26
Cerebral, mesenteric and renal arteries.
Species:  Rat
Technique:  Radioligand binding.
References:  2-3
Heart.
Species:  Rat
Technique:  RT-PCR.
References:  32,59
Brain: Striatum, substantia nigra pars reticulata, globus pallidus, olfactory bulb, amygdala, cerebellar granule cell layer.
Species:  Rat
Technique:  immunocytochemistry.
References:  28
Kidney: Juxtaglomerular apparatus, proximal tubule, distal tubule, cortical collecting duct.
Species:  Rat
Technique:  Immunohistochemistry and immunocytochemistry.
References:  39
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Functional Assays
Measurement of cAMP accumulation in HEK 293 cells transfected with the human D1 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Stimulation of cAMP accumulation.
References:  30,49,61
Measurement of cAMP levels in COS-7 cells transfected with the rat D1 receptor.
Species:  Rat
Tissue:  COS-7 cells.
Response measured:  Stimulation of cAMP accumulation.
References:  36
Measurement of Ca2+ levels in HEK 293 cells transfected with the human D1 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Stimulation of calcium mobilisation.
References:  30,49
Measurement of cAMP levels in CHO cells transfected with the human D1 receptor, using a cAMP response element (CRE)-coupled luciferase construct as the reporter.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of cAMP accumulation.
References:  25
Measurement of cAMP levels in CHO cells transfected with the human D1 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Stimulation of cAMP accumulation.
References:  42
Measurement of IP3 and Ca2+ levels in Xenopus oocytes transfected with the rat D1 receptor.
Species:  Rat
Tissue:  Xenopus oocytes.
Response measured:  Stimulation of IP3 formation and Ca2+ mobilsation.
References:  31
Measurement of PLC activity in Ltk- cells transfected with the rat D1 receptor.
Species:  Rat
Tissue:  LTK- cells.
Response measured:  Stimulation of PLC activity.
References:  58
Measurement of p38 MAPK and JNK levels in SK-N-MC human neuroblastoma cells endogenously expressing the D1 receptor.
Species:  Human
Tissue:  SK-N-MC cells.
Response measured:  Activation of p38 MAPK and JNK signalling pathways.
References:  60
Measurement of [3H]arachidonic acid release from rat striatal neurons endogenously expressing the D1 receptors.
Species:  Rat
Tissue:  Striatal neurons.
Response measured:  Inhibition of [3H]arachidonic acid release.
References:  46
Measurement of cAMP-dependent phosphorylation ex vivo.
Species:  Mouse
Tissue:  Striatum
Response measured:  Increased phosphorylation of DARPP-32 at Thr34 and GluA1 at Ser845.
References:  16,52
Measurement of cAMP-dependent phosphorylation in slice preparations.
Species:  Rat
Tissue:  Striatum
Response measured:  Increased phosphorylation of DARPP-32 at Thr34.
References:  38,52
Physiological Functions
Stimulation of accumulation of cAMP in membrane particles of the rat kidney medulla.
Species:  Rat
Tissue:  Membrane particles of the rat kidney medulla.
References:  4
Modulation of renin release.
Species:  Rat
Tissue:  Renal cortical slices.
References:  6
Induction of circling behaviour.
Species:  Rat
Tissue:  In vivo.
References:  8
Induction of gnawing behaviour and hypermotility.
Species:  Mouse
Tissue:  In vivo.
References:  8
Inhibits Na+-K+-adenosinetriphosphatase (ATPase) activity when a D1 agonist is co-administered with a D2 agonist.
Species:  Rat
Tissue:  Proximal tubule.
References:  10,15
Inhibition of (Na++K+)ATPase activity via synergism with the D2 receptor.
Species:  Rat
Tissue:  Isolated striatal neurons.
References:  11
Modulation of locomotor activity.
Species:  Rat
Tissue:  In vivo.
References:  12
Contribution to pathophysiology and/or maintenance of increased blood pressure in essential hypertension.
Species:  Human
Tissue:  In vivo.
References:  14
Physiological Consequences of Altering Gene Expression
D1 receptor knockout mice exhibit abnormal contextual conditioning.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  23
D1 receptor knockout mice exhibit abnormal passive avoidance behaviour.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  23
D1 receptor knockout mice exhibit hunched posture.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  19
D1 receptor knockout mice exhibit significantly fewer rearing events.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  19
D1 receptor knockout mice exhibit decreased body weight and post-natal growth retardation compared with wild-type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  19-20,23
D1 receptor knockout mice suffer premature death.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  19
D1 receptor knockout mice exhibit dishevelled coats.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  19
D1 receptor knockout mice exhibit abnormal spatial learning.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  20
D1 receptor knockout mice exhibit abnormal dendritic morphology in projection neurones within the anterior cingulate cortex and the pre-frontal cortex.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  48
D1 receptor knockout mice exhibit attenuation of sucrose reinforcement.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  22
D1 receptor knockout mice exhibit reduced motivation for alcohol consumption.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  21
D1 receptor knockout mice exhibit decreased L-DOPA-induced dyskinesia in experimental Parkinsonism.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  17
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Drd1atm1(cre)Rpa Drd1atm1(cre)Rpa/Drd1atm1(cre)Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:99578  MP:0004924 abnormal behavior PMID: 18615733 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
B6.129S4-Drd1a/J
MGI:99578  MP:0005535 abnormal body temperature PMID: 18486343 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000822 abnormal brain ventricle morphology PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0004994 abnormal brain wave pattern PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000788 abnormal cerebral cortex morphology PMID: 17360497 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0001469 abnormal contextual conditioning behavior PMID: 11172752 
Drd1a+|Drd1atm1Jcd Drd1atm1Jcd/Drd1a+
involves: 129S4/SvJae
MGI:99578  MP:0001469 abnormal contextual conditioning behavior PMID: 11172752 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000812 abnormal dentate gyrus morphology PMID: 17360497 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0003119 abnormal digestive system development PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001663 abnormal digestive system physiology PMID: 15272078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0003271 abnormal duodenum morphology PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0000783 abnormal forebrain morphology PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000783 abnormal forebrain morphology PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0000807 abnormal hippocampus morphology PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000807 abnormal hippocampus morphology PMID: 17360497 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0005645 abnormal hypothalamus physiology PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0008802 abnormal intestinal smooth muscle morphology PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000477 abnormal intestine morphology PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0003691 abnormal microglial cell physiology PMID: 17360497 
Drd1a+|Drd1atm1(cre)Rpa|Gad1tm1.1Rpa|Gad1tm1Rpa Drd1atm1(cre)Rpa/Drd1a+,Gad1tm1Rpa/Gad1tm1.1Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:95632  MGI:99578  MP:0001516 abnormal motor coordination/ balance PMID: 18615733 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0003632 abnormal nervous system morphology PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0003633 abnormal nervous system physiology PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0003633 abnormal nervous system physiology PMID: 17360497 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0006009 abnormal neuronal migration PMID: 17409246 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0002799 abnormal passive avoidance behavior PMID: 11172752 
Drd1a+|Drd1atm1Jcd Drd1atm1Jcd/Drd1a+
involves: 129S4/SvJae
MGI:99578  MP:0002799 abnormal passive avoidance behavior PMID: 11172752 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0001504 abnormal posture PMID: 9822743 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd
MGI:99578  MP:0003638 abnormal response/metabolism to endogenous compounds PMID: 8001143 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0001463 abnormal spatial learning PMID: 10585522 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000470 abnormal stomach morphology PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0004077 abnormal striatum morphology PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0004077 abnormal striatum morphology PMID: 17360497 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0004077 abnormal striatum morphology PMID: 7954836 
Drd1atm1Tono Drd1atm1Tono/Drd1atm1Tono
B6.129P2-Drd1a
MGI:99578  MP:0004859 abnormal synaptic plasticity PMID: 19074012 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0009546 absent gastric milk in neonates PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001438 aphagia PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0003354 astrocytosis PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0005156 bradykinesia PMID: 9822743 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0001265 decreased body size PMID: 10585522  11172752 
Drd1atm1(cre)Rpa Drd1atm1(cre)Rpa/Drd1atm1(cre)Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:99578  MP:0001265 decreased body size PMID: 18615733 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0001265 decreased body size PMID: 7954836 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001265 decreased body size PMID: 15272078 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0001262 decreased body weight PMID: 7809078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0001262 decreased body weight PMID: 17360497 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0001262 decreased body weight PMID: 7954836 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0000774 decreased brain size PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0000774 decreased brain size PMID: 17360497 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0000774 decreased brain size PMID: 7954836 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0002175 decreased brain weight PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0002175 decreased brain weight PMID: 17360497 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0005574 decreased breathing frequency PMID: 9822743 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0003910 decreased eating behavior PMID: 15272078 
Drd1a+|Drd1atm1(cre)Rpa|Gad1tm1.1Rpa|Gad1tm1Rpa Drd1atm1(cre)Rpa/Drd1a+,Gad1tm1Rpa/Gad1tm1.1Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:95632  MGI:99578  MP:0010053 decreased grip strength PMID: 18615733 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd
MGI:99578  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 8001143 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
B6.129S4-Drd1a/J
MGI:99578  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 18486343 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
B6.129S4-Drd1a/J
MGI:99578  MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality PMID: 18486343 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0002757 decreased vertical activity PMID: 7809078 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0001511 disheveled coat PMID: 7809078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0005323 dystonia PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0005323 dystonia PMID: 17360497 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000465 gastrointestinal hemorrhage PMID: 15272078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000465 gastrointestinal hemorrhage PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0002183 gliosis PMID: 9822743 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0001505 hunched posture PMID: 7809078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0001399 hyperactivity PMID: 17360497 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0001399 hyperactivity PMID: 7954836 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd
MGI:99578  MP:0001399 hyperactivity PMID: 8001143 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001402 hypoactivity PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0001525 impaired balance PMID: 9822743 
Drd1atm2Rpa Drd1atm2Rpa/Drd1atm2Rpa
involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MGI:99578  MP:0009758 impaired behavioral response to cocaine PMID: 16014726 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd
MGI:99578  MP:0009758 impaired behavioral response to cocaine PMID: 8001143 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6J
MGI:99578  MP:0009758 impaired behavioral response to cocaine PMID: 18045908 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0009747 impaired behavioral response to xenobiotic PMID: 7954836 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6J
MGI:99578  MP:0009747 impaired behavioral response to xenobiotic PMID: 18045908 
Drd1atm2Rpa Drd1atm2Rpa/Drd1atm2Rpa
involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MGI:99578  MP:0009712 impaired conditioned place preference behavior PMID: 16014726 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0001523 impaired righting response PMID: 9822743 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0002574 increased vertical activity PMID: 17360497 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0000512 intestinal ulcer PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0001513 limb grasping PMID: 17360497 
Drd1a+|Drd1atm1(cre)Rpa|Gad1tm1.1Rpa|Gad1tm1Rpa Drd1atm1(cre)Rpa/Drd1a+,Gad1tm1Rpa/Gad1tm1.1Rpa
involves: 129S4/SvJaeSor * C57BL/6
MGI:95632  MGI:99578  MP:0001513 limb grasping PMID: 18615733 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae
MGI:99578  MP:0003246 loss of GABAergic neurons PMID: 17409246 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0000243 myoclonus PMID: 9822743 
Drd1a+|Drd1atm2Jcd Drd1atm2Jcd/Drd1a+
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * CD-1)
MGI:99578  MP:0002169 no abnormal phenotype detected PMID: 9822743 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0001732 postnatal growth retardation PMID: 7809078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001732 postnatal growth retardation PMID: 15272078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0001732 postnatal growth retardation PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(EIIa-cre)C5379Lmgd Drd1atm2Jcd/Drd1a+,Tg(EIIa-cre)C5379Lmgd/0
involves: 129S4/SvJae * BALB/c * CD-1 * FVB/N
MGI:2137685  MGI:99578  MP:0002082 postnatal lethality PMID: 9822743 
Drd1atm1Stl Drd1atm1Stl/Drd1atm1Stl
involves: 129P2/OlaHsd * C57BL/6
MGI:99578  MP:0002082 postnatal lethality PMID: 7954836 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0002082 postnatal lethality PMID: 15272078 
Drd1atm1Jcd Drd1atm1Jcd/Drd1atm1Jcd
involves: 129S4/SvJae * C57BL/6
MGI:99578  MP:0002083 premature death PMID: 7809078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0002083 premature death PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0002064 seizures PMID: 17360497 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MGI:94924  MGI:99578  MP:0003306 small intestinal inflammation PMID: 15272078 
Drd1a+|Drd1atm2Jcd|Tg(Camk2a-cre)2Gsc Drd1atm2Jcd/Drd1a+,Tg(Camk2a-cre)2Gsc/0
involves: 129S4/SvJae * FVB/N
MGI:2181425  MGI:99578  MP:0001512 trunk curl PMID: 17360497 
Biologically Significant Variants
Type:  Single nucleotide polymorphism.
Species:  Human
Description:  Ala48 -> Gly48 polymorphism associated with hypertension.
References:  45
Type:  Single nucleotide polymorphism.
Species:  Human
Description:  5' UTR substitution Ala48 -> Gly48 increases severity of alcohol dependence and promotes sensation-seeking behaviour in alcoholic males.
References:  27,29
Type:  Single nucleotide polymorphism.
Species:  Human
Description:  Ala48 -> Gly48 polymorphism associated with bipolar disorder.
References:  47
General Comments
The gene organisation was established in rat [61] and human [35] and is intronless in the coding region but presents a small intron in the 5'-untranslated region. The promoter region lacks TATA and CAAT boxes and has a high G+C content and consensus sequences for cAMP response element, AP1, AP2 and Sp1 binding sites [35].
Available Assays
DiscoveRx PathHunter® CHO-K1 DRD1 β-Arrestin Cell Line (Cat no. 93-0590C2)
PathHunter® eXpress DRD1 CHO-K1 β-Arrestin GPCR Assay (Cat no. 93-0590E2CP2M)
more info

References

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1. Amenta F, Chiandussi L, Mancini M, Ricci A, Schena M, Veglio F. (1994) Pharmacological characterization and autoradiographic localization of dopamine receptors in the human adrenal cortex. Eur J Endocrinol131: 91-96. [PMID:8038912]

2. Amenta F, Collier WL, Ricci A. (1990) Autoradiographic localization of vascular dopamine receptors. Am J Hypertens3: 34S-36S. [PMID:2200435]

3. Amenta F, Ricci A. (1990) Autoradiographic localization of dopamine DA-1 receptors in the rat renal vasculature using [3H]-SCH 23390 as a ligand. J Auton Pharmacol10: 373-383. [PMID:2151196]

4. Amenta F, Ricci A, Vega JA. (1990) Pharmacological characterization of rat renal medulla dopamine-sensitive cyclic adenosine monophosphate generating system. J Pharmacol Exp Ther253: 246-249. [PMID:2158544]

5. Andersen PH, Jansen JA. (1990) Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. Eur J Pharmacol188: 335-347. [PMID:1973652]

6. Antonipillai I, Broers MI, Lang D. (1989) Evidence that specific dopamine-1 receptor activation is involved in dopamine-induced renin release. Hypertension13: 463-468. [PMID:2566577]

7. Arias-Montaño JA, Floran B, Floran L, Aceves J, Young JM. (2007) Dopamine D(1) receptor facilitation of depolarization-induced release of gamma-amino-butyric acid in rat striatum is mediated by the cAMP/PKA pathway and involves P/Q-type calcium channels. Synapse61: 310-319. [PMID:17318879]

8. Arnt J, Hyttel J, Sánchez C. (1992) Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro. Eur J Pharmacol213: 259-267. [PMID:1355737]

9. Auerbach SS, DrugMatrix® and ToxFX® Coordinator National Toxicology Program. National Toxicoligy Program: Dept of Health and Human Services. Accessed on 02/05/2014. Modified on 02/05/2014. DrugMatrix, https://ntp.niehs.nih.gov/drugmatrix/index.html

10. Bertorello A, Aperia A. (1990) Inhibition of proximal tubule Na(+)-K(+)-ATPase activity requires simultaneous activation of DA1 and DA2 receptors. Am J Physiol259: F924-F928. [PMID:1979719]

11. Bertorello AM, Hopfield JF, Aperia A, Greengard P. (1990) Inhibition by dopamine of (Na(+)+K+)ATPase activity in neostriatal neurons through D1 and D2 dopamine receptor synergism. Nature347: 386-388. [PMID:1977083]

12. Breese GR, Duncan GE, Napier TC, Bondy SC, Iorio LC, Mueller RA. (1987) 6-hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1- and D2-dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding. J Pharmacol Exp Ther240: 167-176. [PMID:3100767]

13. Brown JH, Makman MH. (1973) Stimulation by dopamine of adenylate cyclase in retinal homogenates and of adenosine-3':5'-cyclic monophosphate formation in intact retina. Proc. Natl. Acad. Sci. U.S.A.69: 539-543. [PMID:4401122]

14. Carey RM, Stote RM, Dubb JW, Townsend LH, Rose CE, Kaiser DL. (1984) Selective peripheral dopamine-1 receptor stimulation with fenoldopam in human essential hypertension. J Clin Invest74: 2198-2207. [PMID:6150942]

15. Chen C, Lokhandwala MF. (1993) Inhibition of Na+,K(+)-ATPase in rat renal proximal tubules by dopamine involved DA-1 receptor activation. Naunyn Schmiedebergs Arch Pharmacol347: 289-295. [PMID:8097567]

16. Corvol JC, Valjent E, Pascoli V, Robin A, Stipanovich A, Luedtke RR, Belluscio L, Girault JA, Hervé D. (2007) Quantitative changes in Galphaolf protein levels, but not D1 receptor, alter specifically acute responses to psychostimulants. Neuropsychopharmacology32 (5): 1109-21. [PMID:17063155]

17. Darmopil S, Martín AB, De Diego IR, Ares S, Moratalla R. (2009) Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation. Biol. Psychiatry66 (6): 603-13. [PMID:19520364]

18. Dearry A, Gringrich JA, Falardeau P, Fremeau RT, Bates MD, Caron MG. (1990) Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature347: 72-76. [PMID:2144334]

19. Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE, Ooi GT, Grinberg A, Lee EJ, Huang SP. (1994) Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci U S A91: 12564-12568. [PMID:7809078]

20. El-Ghundi M, Fletcher PJ, Drago J, Sibley DR, O'Dowd BF, George SR. (1999) Spatial learning deficit in dopamine D(1) receptor knockout mice. Eur J Pharmacol383: 95-106. [PMID:10585522]

21. El-Ghundi M, George SR, Drago J, Fletcher PJ, Fan T, Nguyen T, Liu C, Sibley DR, Westphal H, O'Dowd BF. (1998) Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior. Eur J Pharmacol353: 149-158. [PMID:9726645]

22. El-Ghundi M, O'Dowd BF, Erclik M, George SR. (2003) Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice. Eur J Neurosci17: 851-862. [PMID:12603275]

23. El-Ghundi M, O'Dowd BF, George SR. (2001) Prolonged fear responses in mice lacking dopamine D1 receptor. Brain Res892: 86-93. [PMID:11172752]

24. Flores-Hernández J, Cepeda C, Hernández-Echeagaray E, Calvert CR, Jokel ES, Fienberg AA, Greengard P, Levine MS. (2002) Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32. J Neurophysiol88: 3010-3020. [PMID:12466426]

25. Himmler A, Stratowa C, Czernilofsky AP. (1993) Functional testing of human dopamine D1 and D5 receptors expressed in stable cAMP-responsive luciferase reporter cell lines. J Recept Res13: 79-94. [PMID:8383768]

26. Hyun JS, Baig MR, Yang DY, Leungwattanakij S, Kim KD, Abdel-Mageed AB, Bivalacqua TJ, Hellstrom WJ. (2002) Localization of peripheral dopamine D1 and D2 receptors in rat and human seminal vesicles. J Androl23: 114-120. [PMID:11783439]

27. Kim DJ, Park BL, Yoon S, Lee HK, Joe KH, Cheon YH, Gwon DH, Cho SN, Lee HW, NamGung S, Shin HD. (2007) 5' UTR polymorphism of dopamine receptor D1 (DRD1) associated with severity and temperament of alcoholism. Biochem Biophys Res Commun357: 1135-1141. [PMID:17466946]

28. Levey AI, Hersch SM, Rye DB, Sunahara RK, Niznik HB, Kitt CA, Price DL, Maggio R, Brann MR, Ciliax BJ et al.. (1993) Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. Proc. Natl. Acad. Sci. U.S.A.90: 8861-8865. [PMID:8415621]

29. Limosin F, Loze JY, Rouillon F, Adès J, Gorwood P. (2003) Association between dopamine receptor D1 gene DdeI polymorphism and sensation seeking in alcohol-dependent men. Alcohol Clin Exp Res27: 1226-1228. [PMID:12966314]

30. Lin CW, Miller TR, Witte DG, Bianchi BR, Stashko M, Manelli AM, Frail DE. (1995) Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells. Mol Pharmacol47: 131-139. [PMID:7838121]

31. Mahan LC, Burch RM, Monsma FJ, Sibley DR. (1990) Expression of striatal D1 dopamine receptors coupled to inositol phosphate production and Ca2+ mobilization in Xenopus oocytes. Proc Natl Acad Sci U S A87: 2196-2200. [PMID:1690425]

32. Matsumoto T, Ozono R, Sasaki N, Oshima T, Matsuura H, Kajiyama G, Carey RM, Kambe M. (2000) Type 1A dopamine receptor expression in the heart is not altered in spontaneously hypertensive rats. Am J Hypertens13: 673-677. [PMID:10912752]

33. Medvedev IO, Ramsey AJ, Masoud ST, Bermejo MK, Urs N, Sotnikova TD, Beaulieu JM, Gainetdinov RR, Salahpour A. (2013) D1 dopamine receptor coupling to PLCβ regulates forward locomotion in mice. J. Neurosci.33 (46): 18125-33. [PMID:24227722]

34. Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A. (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther303: 791-804. [PMID:12388666]

35. Minowa MT, Minowa T, Monsma FJ, Sibley DR, Mouradian MM. (1992) Characterization of the 5' flanking region of the human D1A dopamine receptor gene. Proc. Natl. Acad. Sci. U.S.A.89: 3045-3049. [PMID:1557411]

36. Monsma FJ, Mahan LC, McVittie LD, Gerfen CR, Sibley DR. (1990) Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation. Proc. Natl. Acad. Sci. U.S.A.87: 6723-6727. [PMID:2168556]

37. Nergårdh R, Oerther S, Fredholm BB. (2005) Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors. Pharmacol. Biochem. Behav.82 (3): 495-505. [PMID:16318870]

38. Nishi A, Snyder GL, Greengard P. (1997) Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J. Neurosci.17 (21): 8147-55. [PMID:9334390]

39. O'Connell DP, Botkin SJ, Ramos SI, Sibley DR, Ariano MA, Felder RA, Carey RM. (1995) Localization of dopamine D1A receptor protein in rat kidneys. Am J Physiol268: F1185-F1197. [PMID:7611459]

40. O'Sullivan GJ, Dunleavy M, Hakansson K, Clementi M, Kinsella A, Croke DT, Drago J, Fienberg AA, Greengard P, Sibley DR et al.. (2008) Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling. Neuropharmacology54 (7): 1051-61. [PMID:18367215]

41. Ozono R, O'Connell DP, Wang ZQ, Moore AF, Sanada H, Felder RA, Carey RM. (1997) Localization of the dopamine D1 receptor protein in the human heart and kidney. Hypertension30: 725-729. [PMID:9323013]

42. Pedersen UB, Norby B, Jensen AA, Schiødt M, Hansen A, Suhr-Jessen P, Scheideler M, Thastrup O, Andersen PH. (1994) Characteristics of stably expressed human D1a and D1b receptors: atypical behavior of the dopamine D1b receptor. Eur. J. Pharmacol.267: 85-93. [PMID:8206133]

43. Santini E, Feyder M, Gangarossa G, Bateup HS, Greengard P, Fisone G. (2012) Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism. J. Biol. Chem.287 (33): 27806-12. [PMID:22753408]

44. Santini E, Heiman M, Greengard P, Valjent E, Fisone G. (2009) Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia. Sci Signal2 (80): ra36. [PMID:19622833]

45. Sato M, Soma M, Nakayama T, Kanmatsuse K. (2000) Dopamine D1 receptor gene polymorphism is associated with essential hypertension. Hypertension36: 183-186. [PMID:10948075]

46. Schinelli S, Paolillo M, Corona GL. (1994) Opposing actions of D1- and D2-dopamine receptors on arachidonic acid release and cyclic AMP production in striatal neurons. J Neurochem62: 944-949. [PMID:8113815]

47. Severino G, Congiu D, Serreli C, De Lisa R, Chillotti C, Del Zompo M, Piccardi MP. (2005) A48G polymorphism in the D1 receptor genes associated with bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet134: 37-38. [PMID:15704231]

48. Stanwood GD, Parlaman JP, Levitt P. (2005) Anatomical abnormalities in dopaminoceptive regions of the cerebral cortex of dopamine D1 receptor mutant mice. J Comp Neurol487: 270-282. [PMID:15892099]

49. Sun WC, Jin L, Cao Y, Wang LZ, Meng F, Zhu XZ. (2005) Cloning, expression, and functional analysis of human dopamine D1 receptors. Acta Pharmacol Sin26: 27-32. [PMID:15659110]

50. Sunahara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HH, Niznik HB. (1991) Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature350: 614-619. [PMID:1826762]

51. Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL, Israel Y, Seeman P, O'Dowd BF. (1990) Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature347: 80-83. [PMID:1975640]

52. Svenningsson P, Lindskog M, Rognoni F, Fredholm BB, Greengard P, Fisone G. (1998) Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons. Neuroscience84 (1): 223-8. [PMID:9522376]

53. Tiberi M, Caron MG. (1994) High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. J. Biol. Chem.269: 27925-27931. [PMID:7525564]

54. Tice MA, Hashemi T, Taylor LA, Duffy RA, McQuade RD. (1994) Characterization of the binding of SCH 39166 to the five cloned dopamine receptor subtypes. Pharmacol. Biochem. Behav.49 (3): 567-71. [PMID:7862709]

55. Undie AS, Friedman E. (1990) Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain. J. Pharmacol. Exp. Ther.253 (3): 987-92. [PMID:1972756]

56. Valjent E, Pascoli V, Svenningsson P, Paul S, Enslen H, Corvol JC, Stipanovich A, Caboche J, Lombroso PJ, Nairn AC et al.. (2005) Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc. Natl. Acad. Sci. U.S.A.102 (2): 491-6. [PMID:15608059]

57. Veruki ML, Wässle H. (1996) Immunohistochemical localization of dopamine D1 receptors in rat retina. Eur J Neurosci8: 2286-2297. [PMID:8950093]

58. Yu PY, Eisner GM, Yamaguchi I, Mouradian MM, Felder RA, Jose PA. (1996) Dopamine D1A receptor regulation of phospholipase C isoform. J Biol Chem271: 19503-19508. [PMID:8702641]

59. Zhang H, Qiao Z, Zhao Y, Zhao R. (1996) Transcription of dopamine D1A receptor mRNAs in rat heart. Methods Find Exp Clin Pharmacol18: 183-187. [PMID:8738069]

60. Zhen X, Uryu K, Wang HY, Friedman E. (1998) D1 dopamine receptor agonists mediate activation of p38 mitogen-activated protein kinase and c-Jun amino-terminal kinase by a protein kinase A-dependent mechanism in SK-N-MC human neuroblastoma cells. Mol Pharmacol54: 453-458. [PMID:9730903]

61. Zhou QZ, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, Pribnow D, Salon J, Bunzow J. (1990) Cloning and expression of human and rat D1 dopamine receptors. Nature347: 76-86. [PMID:2168520]

How to cite this page

Arvid Carlsson, Marc G. Caron, Olivier Civelli, John W. Kebabian, Saloman Z. Langer, Bernard Scatton, Jean-Charles Schwartz, Goran Sedvall, Philip Seeman, Pierre Sokoloff, Pierre F. Spano, Hubert H. M. Van Tol.
Dopamine receptors: D1 receptor. Last modified on 12/05/2014. Accessed on 31/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=214.