TRH   Click here for help

GtoPdb Ligand ID: 2139

Synonyms: thyroliberin
Approved drug
TRH is an approved drug (FDA (1976))
Comment: This structure matches the structure deposited with the INN record for protirelin, which is synthetic TRH.
Species: Human, Mouse, Rat
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES O=C1CCC(N1)C(=O)NC(C(=O)N1CCCC1C(=O)N)Cc1nc[nH]c1
Isomeric SMILES O=C1CC[C@H](N1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N)Cc1nc[nH]c1
InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
InChI Key XNSAINXGIQZQOO-SRVKXCTJSA-N
Natural/Endogenous Targets
Target
TRH1 receptor
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRH1 receptor Primary target of this compound Ligand is endogenous in the given species Rn Agonist Full agonist 7.4 pKi - 4
pKi 7.4 [4]
TRH2 receptor Rn Agonist Full agonist 7.4 pKi - 4
pKi 7.4 [4]
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields