linaclotide

Ligand id: 5017

Name: linaclotide

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Classification
Compound class Peptide or derivative
Approved drug? Yes (FDA and EMA (2012))
International Nonproprietary Names
INN number INN
8802 linaclotide
Synonyms
Constella® | Linzess® | MM-416775
Database Links
CAS Registry No. 851199-59-2 (source: Scifinder)
DrugBank Ligand DB08890
GtoPdb PubChem SID 178101714
PubChem CID 16158208
Search PubMed clinical trials linaclotide
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Wikipedia Linaclotide
Comments
Linaclotide represents a first-in-class, oral guanylate cyclase 2C activator [2]. It is a synthetic analogue of pathological heat-stable bacterial enterotoxins, and retains the same intrachain disulfide bond structure essential for biological activity.
Marketed formulations contain linaclotide acetate (PubChem CID 16158207).