Natriuretic peptide receptor family
Natriuretic peptide receptors (provisional nomenclature) are a family (ENSFM00250000000198) of homodimeric, catalytic receptors with a single TM domain and guanylyl cyclase (EC 4.6.1.2) activity on the intracellular domain of the protein sequence. Isoforms are activated by the peptide hormones atrial natriuretic peptide (ANP, ENSG00000175206), brain natriuretic peptide (BNP, ENSG00000120937) and C-type natriuretic peptide (CNP, ENSG00000163273). Another family member is GC-C, the receptor for guanylin (ENSG00000113389) and uroguanylin (ENSG00000044012). Family members have conserved ligand-binding, catalytic (guanylyl cyclase) and regulatory domains with the exception of NPR-C which has an extracellular binding domain homologous to that of other NPRs, but with a truncated intracellular domain which appears to couple, via the Gi/o family of G-proteins, to activation of phospholipase C, inwardly-rectifying potassium channels and inhibition of adenylyl cyclase activity [11].
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Receptors 
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
guanylate cyclase 2C (heat stable enterotoxin receptor) Show »« Hide
|
Hunt, DM; Buch, P; Michaelides, M. (2010) Guanylate cyclases and associated activator proteins in retinal disease. Mol. Cell. Biochem., 334 (1-2): 157-68. [PMID:19941038]
Kishimoto, I; Tokudome, T; Nakao, K; Kangawa, K. (2011) Natriuretic peptide system: an overview of studies using genetically engineered animal models. FEBS J., 278 (11): 1830-41. [PMID:21477073]
Kuhn, M. (2009) Function and dysfunction of mammalian membrane guanylyl cyclase receptors: lessons from genetic mouse models and implications for human diseases. Handb Exp Pharmacol, (191): 47-69. [PMID:19089325]
Lanfear, DE. (2010) Genetic variation in the natriuretic peptide system and heart failure. Heart Fail Rev, 15 (3): 219-28. [PMID:18850266]
Li, P; Lin, JE; Marszlowicz, GP; Valentino, MA; Chang, C; Schulz, S; Pitari, GM; Waldman, SA. (2009) GCC signaling in colorectal cancer: Is colorectal cancer a paracrine deficiency syndrome?. Drug News Perspect., 22 (6): 313-8. [PMID:19771320]
Misono, KS; Philo, JS; Arakawa, T; Ogata, CM; Qiu, Y; Ogawa, H; Young, HS. (2011) Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase. FEBS J., 278 (11): 1818-29. [PMID:21375693]
Pandey, KN. (2011) The functional genomics of guanylyl cyclase/natriuretic peptide receptor-A: perspectives and paradigms. FEBS J., 278 (11): 1792-807. [PMID:21375691]
Potter, LR. (2011) Natriuretic peptide metabolism, clearance and degradation. FEBS J., 278 (11): 1808-17. [PMID:21375692]
Potter, LR; Yoder, AR; Flora, DR; Antos, LK; Dickey, DM. (2009) Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handb Exp Pharmacol, (191): 341-66. [PMID:19089336]
Rubattu, S; Sciarretta, S; Morriello, A; Calvieri, C; Battistoni, A; Volpe, M. (2010) NPR-C: a component of the natriuretic peptide family with implications in human diseases. J. Mol. Med., 88 (9): 889-97. [PMID:20563546]
Saito, Y. (2010) Roles of atrial natriuretic peptide and its therapeutic use. J Cardiol, 56 (3): 262-70. [PMID:20884176]
van Kimmenade, RR; Januzzi, JL. (2009) The evolution of the natriuretic peptides - Current applications in human and animal medicine. J Vet Cardiol, 11 Suppl 1: S9-21. [PMID:19285934]
1. Delporte, C; Poloczek, P; Gossen, D; Tastenoy, M; Winand, J; Christophe, J. (1991) Characterization and regulation of atrial natriuretic peptide (ANP)-R1 receptors in the human neuroblastoma cell line NB-OK-1. Eur. J. Pharmacol., 207 (1): 81-8. [PMID:1680722]
2. Deschênes, J; Duperé, C; McNicoll, N; L'Heureux, N; Auger, F; Fournier, A; De Léan, A. (2005) Development of a selective peptide antagonist for the human natriuretic peptide receptor-B. Peptides, 26 (3): 517-24. [PMID:15652659]
3. Drewett, JG; Fendly, BM; Garbers, DL; Lowe, DG. (1995) Natriuretic peptide receptor-B (guanylyl cyclase-B) mediates C-type natriuretic peptide relaxation of precontracted rat aorta. J. Biol. Chem., 270 (9): 4668-74. [PMID:7876238]
4. Harris, LA; Crowell, MD. (2007) Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation. Curr. Opin. Mol. Ther., 9 (4): 403-10. [PMID:17694454]
5. Hobbs, A; Foster, P; Prescott, C; Scotland, R; Ahluwalia, A. (2004) Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation, 110 (10): 1231-5. [PMID:15337698]
6. Hunt, DM; Buch, P; Michaelides, M. (2010) Guanylate cyclases and associated activator proteins in retinal disease. Mol. Cell. Biochem., 334 (1-2): 157-68. [PMID:19941038]
7. Kambayashi, Y; Nakajima, S; Ueda, M; Inouye, K. (1989) A dicarba analog of beta-atrial natriuretic peptide (beta-ANP) inhibits guanosine 3',5'-cyclic monophosphate production induced by alpha-ANP in cultured rat vascular smooth muscle cells. FEBS Lett., 248 (1-2): 28-34. [PMID:2542088]
8. Maack, T; Suzuki, M; Almeida, FA; Nussenzveig, D; Scarborough, RM; McEnroe, GA; Lewicki, JA. (1987) Physiological role of silent receptors of atrial natriuretic factor. Science, 238 (4827): 675-8. [PMID:2823385]
9. Moffatt, P; Thomas, G; Sellin, K; Bessette, MC; Lafrenière, F; Akhouayri, O; St-Arnaud, R; Lanctôt, C. (2007) Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. J. Biol. Chem., 282 (50): 36454-62. [PMID:17951249]
10. Morishita, Y; Sano, T; Ando, K; Saitoh, Y; Kase, H; Yamada, K; Matsuda, Y. (1991) Microbial polysaccharide, HS-142-1, competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor. Biochem. Biophys. Res. Commun., 176 (3): 949-57. [PMID:1674870]
11. Murthy, KS; Makhlouf, GM. (1999) Identification of the G protein-activating domain of the natriuretic peptide clearance receptor (NPR-C). J. Biol. Chem., 274 (25): 17587-92. [PMID:10364194]
12. Olson, LJ; Lowe, DG; Drewett, JG. (1996) Novel natriuretic peptide receptor/guanylyl cyclase A-selective agonist inhibits angiotensin II- and forskolin-evoked aldosterone synthesis in a human zona glomerulosa cell line. Mol. Pharmacol., 50 (2): 430-5. [PMID:8700153]
13. Suga, S; Nakao, K; Hosoda, K; Mukoyama, M; Ogawa, Y; Shirakami, G; Arai, H; Saito, Y; Kambayashi, Y; Inouye, K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]
14. Veale, CA; Alford, VC; Aharony, D; Banville, DL; Bialecki, RA; Brown, FJ; Damewood, JR; Dantzman, CL; Edwards, PD; Jacobs, RT; et al.. (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg. Med. Chem. Lett., 10 (17): 1949-52. [PMID:10987424]
15. Wyss, DF; Lahm, HW; Manneberg, M; Labhardt, AM. (1991) Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J. Antibiot., 44 (2): 172-80. [PMID:1826288]
|
 @GuidetoPHARM  Like us on Facebook Privacy and Cookie Policy |
The polysaccharide obtained from fermentation of Aureobasidium species, HS142-1, acts as an antagonist at both NPR-A and NPR-B receptors [10].
Gucy2D (RetGC1, GC-E, ENSG00000132518) and Gucy2F (RetGC2, GC-F, ENSG00000101890) are predominantly retinal guanylyl cyclase activities, which are inhibited by calcium ions acting through the guanylyl cyclase activating peptides GCAP1 (GUCA1A, ENSG00000048545), GCAP2 (GUCA1B, ENSG00000112599) and GCAP3 (GUCA1C, ENSG00000138472) [6].