Ligand id: 5017

Name: linaclotide

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View more information in the IUPHAR Pharmacology Education Project: linactolide

1. Bharucha AE, Waldman SA. (2010)
Taking a lesson from microbial diarrheagenesis in the management of chronic constipation.
Gastroenterology, 138 (3): 813-7. [PMID:20114092]
2. Busby RW, Bryant AP, Bartolini WP, Cordero EA, Hannig G, Kessler MM, Mahajan-Miklos S, Pierce CM, Solinga RM, Sun LJ et al.. (2010)
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.
Eur. J. Pharmacol., 649 (1-3): 328-35. [PMID:20863829]
3. Harris LA, Crowell MD. (2007)
Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation.
Curr. Opin. Mol. Ther., 9 (4): 403-10. [PMID:17694454]
4. Shailubhai K. (2002)
Therapeutic applications of guanylate cyclase-C receptor agonists.
Curr Opin Drug Discov Devel, 5 (2): 261-8. [PMID:11926132]