apixaban

Ligand id: 6390

Name: apixaban

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 110.76
Molecular weight 459.19
XLogP 2.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: EMA (2011), FDA (2012))
IUPAC Name
1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
International Nonproprietary Names
INN number INN
8626 apixaban
Synonyms
BMS-562247
Eliquis®
Database Links
CAS Registry No. 503612-47-3 (source: PubChem)
ChEBI CHEBI:72296
ChEMBL Ligand CHEMBL231779
DrugBank Ligand DB06605
PubChem CID 10182969
RCSB PDB Ligand GG2
Search Google for chemical match using the InChIKey QNZCBYKSOIHPEH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QNZCBYKSOIHPEH
Search PubMed clinical trials apixaban
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Wikipedia Apixaban
Comments
Apixaban belongs to the direct factor Xa inhibitor family of drugs, which also includes rivaroxaban and edoxaban.