apixaban

Ligand id: 6390

Name: apixaban

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 110.76
Molecular weight 459.19
XLogP 2.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
coagulation factor X Inhibitor Inhibition 10.1 pKi - 2
pKi 10.1 (Ki 8x10-11 M) [2]
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Affinity Units Concentration range (M) Reference
andexanet alfa Hs Inhibitor Binding 9.2 pKd - 1
pKd 9.2 (Kd 5.8x10-10 M) [1]
Description: Enzyme assays using purified human plasma fXa, inhibited by apixaban.