hydroxychloroquine

Home
Ligands
hydroxychloroquine

Ligand id: 7198

Name: hydroxychloroquine

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	9
Topological polar surface area	48.39
Molecular weight	335.18
XLogP	3.02
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: FDA (1955))

IUPAC Name
2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol

IUPAC Name

2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol

International Nonproprietary Names
INN number	INN
796	hydroxychloroquine

Synonyms
Dolquine®
Plaquenil®

Synonyms

Dolquine®

Plaquenil®

Database Links
CAS Registry No.	118-42-3
ChEMBL Ligand	CHEMBL1535
DrugBank Ligand	DB01611
PubChem CID	3652
Search Google for chemical match using the InChIKey	XXSMGPRMXLTPCZ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	XXSMGPRMXLTPCZ
Search PubMed clinical trials	hydroxychloroquine
Search PubMed titles	hydroxychloroquine
Search PubMed titles/abstracts	hydroxychloroquine
Wikipedia	Hydroxychloroquine

Comments
Although this drug has direct effects on survival of the malaria parasite it also appears to be an antagonist of two of the human TOLL-like receptors (TLR7 and TLR9). Antagonism of these receptors is likely related to the anti-inflammatory action of this drug in some auto-immune diseases.

Comments

Although this drug has direct effects on survival of the malaria parasite it also appears to be an antagonist of two of the human TOLL-like receptors (TLR7 and TLR9). Antagonism of these receptors is likely related to the anti-inflammatory action of this drug in some auto-immune diseases.