Ligand id: 7198

Name: hydroxychloroquine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 48.39
Molecular weight 335.18
XLogP 3.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Hydroxychloroquine is used to treat or prevent malaria, and is also used to treat discoid lupus erythematosus and rheumatoid arthritis.
Mechanism Of Action and Pharmacodynamic Effects
Antagonism of TOLL-like receptors TLR7 and TLR9 is likely related to the anti-inflammatory action of this drug, as these receptors have been implicated in initiating the inflammatory reaction to 'self' molecules [1].
External links