Ligand id: 7198

Name: hydroxychloroquine

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View more information in the IUPHAR Pharmacology Education Project: hydroxychloroquine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 48.39
Molecular weight 335.18
XLogP 3.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TLR9 Antagonist Antagonist 7.1 pIC50 - 2
pIC50 7.1 (IC50 8x10-8 M) [2]
Description: Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.
TLR7 Antagonist Antagonist 5.6 pIC50 - 2
pIC50 5.6 (IC50 2.78x10-6 M) [2]
Description: Inhibition of hTLR7 R848-induced luciferase reporter gene activation.