hydroxychloroquine

Ligand id: 7198

Name: hydroxychloroquine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 48.39
Molecular weight 335.18
XLogP 3.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at catalytic receptors
Key to terms and symbols Click on species/strain names for details Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TLR9 Hs Antagonist Antagonist 7.1 pIC50 - 2
pIC50 7.1 (IC50 8x10-8 M) [2]
Description: Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.
TLR7 Hs Antagonist Antagonist 5.6 pIC50 - 2
pIC50 5.6 (IC50 2.78x10-6 M) [2]
Description: Inhibition of hTLR7 R848-induced luciferase reporter gene activation.