AZD0328

Ligand id: 7697

Name: AZD0328

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 25.36
Molecular weight 216.13
XLogP 1.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(8R)-spiro[1-azabicyclo[2.2.2]octane-8,2'-3H-furo[5,4-b]pyridine]
Synonyms
AZD 0328 | AZD-0328
Comments
AZD0328 is a nicotinic acetylcholine receptor alpha 7 (α7 nAChR) agonist. AZD0328 was developed as a potential treatment for the cognitive impairment associated with diseases such as schizophrenia and Alzheimer's disease. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
Database Links
CAS Registry No. 220099-91-2
ChEMBL Ligand CHEMBL2151437
GtoPdb PubChem SID 223366030
PubChem CID 9794392
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