AZD0328

Ligand id: 7697

Name: AZD0328

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 25.36
Molecular weight 216.13
XLogP 1.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(8R)-spiro[1-azabicyclo[2.2.2]octane-8,2'-3H-furo[5,4-b]pyridine]
Synonyms
AZD 0328 | AZD-0328
Database Links
CAS Registry No. 220099-91-2
ChEMBL Ligand CHEMBL2151437
PubChem CID 9794392
Search Google for chemical match using the InChIKey OCKIPDMKGPYYJS-ZDUSSCGKSA-N
Search Google for chemicals with the same backbone OCKIPDMKGPYYJS
Search UniChem for chemical match using the InChIKey OCKIPDMKGPYYJS-ZDUSSCGKSA-N
Search UniChem for chemicals with the same backbone OCKIPDMKGPYYJS
Comments
AZD0328 is a nicotinic acetylcholine receptor alpha 7 (α7 nAChR) agonist. AZD0328 was developed as a potential treatment for the cognitive impairment associated with diseases such as schizophrenia and Alzheimer's disease. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.