AZD0328

Ligand id: 7697

Name: AZD0328

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 25.36
Molecular weight 216.13
XLogP 1.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Mazurov AA, Speake JD, Yohannes D. (2011)
Discovery and development of α7 nicotinic acetylcholine receptor modulators.
J. Med. Chem.54 (23): 7943-61. [PMID:21919481]
2. Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP et al.. (2009)
Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.
Biochem. Pharmacol.78 (7): 880-8. [PMID:19615981]