compound 5 [PMID: 17618114]

Ligand id: 9348

Name: compound 5 [PMID: 17618114]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 87.08
Molecular weight 439.14
XLogP 4.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
Tie2 kinase inhibitor
Comments
Compound 5 [PMID: 17618114] is an inhibitor of TEK receptor tyrosine kinase (a.k.a. TIE2) [1]. Compound 5 was SAR optimised from lead SB203580. Small molecule Tie2 inhibitors are being developed for potential use as anti-angiogenic cancer therapeutics.
Database Links
ChEMBL Ligand CHEMBL237352
GtoPdb PubChem SID 328083450
PubChem CID 23625762
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