compound 5 [PMID: 17618114]

Ligand id: 9348

Name: compound 5 [PMID: 17618114]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 87.08
Molecular weight 439.14
XLogP 4.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Compound 5 exhibits moderate cellular activity, and is anti-angiogenic in mouse models of angiogenesis and cancer (plasmacytoma xenograft) [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TEK receptor tyrosine kinase Hs Inhibitor Inhibition 6.6 pIC50 - 1
pIC50 6.6 (IC50 2.5x10-7 M) [1]