Synonyms: drosophilin B | pleuromutilin
Compound class:
Natural product or derivative
Comment: Pleuromulin (also known as pleuromutilin) was initially isolated from fungal species of the genus Pleurotus and was the first pleuromutilin class antibacterial to be discovered [1]. Further optimization of pleuromulin led to the development of the clinically approved medicines lefamulin and retapamulin.
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Bioactivity Comments |
Pleuromulin has antibacterial activity against Gram-positive bacteria, including staphylococcal species such as methicillin resistant Staphylococcus aureus (MRSA) [1-2]. |