Synonyms: drosophilin B | pleuromutilin
Compound class:
Natural product or derivative
Comment: Pleuromulin (also known as pleuromutilin) was initially isolated from fungal species of the genus Pleurotus and was the first pleuromutilin class antibacterial to be discovered [1]. Further optimization of pleuromulin led to the development of the clinically approved medicines lefamulin and retapamulin.
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
Pleuromutilins bind to the peptidyl transferase center (PTC) of the bacterial 50S ribosomal subunit, leading to inhibition of peptide bond formation [2]. |