U46619

Ligand id: 1888

Name: U46619

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 12
Topological polar surface area 66.76
Molecular weight 350.25
XLogP 4.63
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TP receptor Hs Agonist Full agonist 7.5 pKi - 1
pKi 7.5 [1]
TP receptor Mm Agonist Full agonist 7.2 pKi - 3
pKi 7.2 [3]
FP receptor Hs Agonist Full agonist 6.6 pKi - 1
pKi 6.6 [1]
FP receptor Mm Agonist Full agonist 6.0 pKi - 3
pKi 6.0 [3]
EP4 receptor Hs Agonist Full agonist 5.7 pKi - 1
pKi 5.7 [1]
DP1 receptor Hs Agonist Full agonist 5.4 – 5.9 pKi - 1,5
pKi 5.4 – 5.9 [1,5]
EP4 receptor Rn Agonist Full agonist 5.6 pKi - 2
pKi 5.6 [2]
DP2 receptor Hs Agonist Full agonist 5.5 pKi - 4
pKi 5.5 [4]
EP1 receptor Rn Agonist Full agonist 5.2 pKi - 2
pKi 5.2 [2]
EP2 receptor Rn Agonist Full agonist 5.1 pKi - 2
pKi 5.1 [2]
EP2 receptor Hs Agonist Full agonist 4.9 pKi - 1
pKi 4.9 [1]
EP3 receptor Hs Agonist Full agonist 4.9 pKi - 1
pKi 4.9 [1]
EP3 receptor Rn Agonist Full agonist 4.8 pKi - 2
pKi 4.8 (Ki 1.62x10-5 M) EP3α isoform [2]
EP1 receptor Hs Agonist Full agonist 4.5 pKi - 1
pKi 4.5 [1]
IP receptor Hs Agonist Full agonist 4.2 pKi - 1
pKi 4.2 [1]
EP3 receptor Rn Agonist Full agonist 6.8 pEC50 - 2
pEC50 6.8 (EC50 1.49x10-7 M) EP3α isoform [2]
Ligand mentioned in the following text fields