Prostanoid receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [86]) are activated by the endogenous ligands prostaglandins PGD2, PGE2 , PGF, PGH2, prostacyclin [PGI2] and thromboxane A2. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.

Receptors

DP1 receptor Show summary » More detailed page

DP2 receptor Show summary » More detailed page

EP1 receptor Show summary » More detailed page

EP2 receptor Show summary » More detailed page

EP3 receptor Show summary » More detailed page

EP4 receptor Show summary » More detailed page

FP receptor Show summary » More detailed page

IP receptor Show summary » More detailed page

TP receptor Show summary » More detailed page

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Xavier Norel, Mark Abramovitz, Richard M. Breyer, Lucie Clapp, Robert A. Coleman, Mark Giembycz, Robert L. Jones, Shuh Narumiya, Roy Pettipher, Yukihiko Sugimoto, David F. Woodward, Rebecca Hills. Prostanoid receptors. Accessed on 31/08/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=58.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.