Prostanoid receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Prostanoid receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors, [17]) are activated by the endogenous ligands prostaglandins PGD2, PGE2 , PGF, PGH2, prostacyclin [PGI2] and thromboxane A2. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.

Receptors

DP1 receptor Show summary » More detailed page

DP2 receptor Show summary » More detailed page

EP1 receptor Show summary » More detailed page

EP2 receptor Show summary » More detailed page

EP3 receptor Show summary » More detailed page

EP4 receptor Show summary » More detailed page

FP receptor Show summary » More detailed page

IP1 receptor Show summary » More detailed page

TP receptor Show summary » More detailed page

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Prostanoid receptors. Accessed on 30/08/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=58.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.