Ro 25-1553   Click here for help

GtoPdb Ligand ID: 2259

Synonyms: Ac-His1[Glu8,Lys12,Nle17,Ala19,Asp25,Leu26,Lys27,28,Gly29,30,Thr31]VIP-NH2(cyclo 21-25) | Ro 251553 | Ro-251553
Compound class: Peptide or derivative
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
VPAC2 receptor Hs Agonist Agonist 8.3 – 8.7 pEC50 - 2-3
⤷ pEC50 8.7 (EC50 2x10-9 M) [3]
Description: stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
pEC50 8.3 (EC50 5x10-9 M) [2]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
PAC1 receptor Hs Agonist Agonist <6.0 pEC50 - 3
⤷ pEC50 <6.0 (EC50 >1x10-6 M) [3]
Description: stimulation of cyclic AMP formation in NIH/3T3 cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Partial agonist <6.0 pEC50 - 2-3
⤷ pEC50 <6.0 (EC50 >1x10-6 M) [3]
Description: stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
pEC50 6.0 (EC50 1x10-6 M) [2]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
VPAC2 receptor Hs Agonist Agonist 7.8 – 9.5 pIC50 - 1-3
⤷ pIC50 7.8 – 9.5 (IC50 1.5x10-8 – 3x10-10 M) [1-3]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Partial agonist <6.0 – 7.0 pIC50 - 1-3
⤷ pIC50 7.0 (IC50 1x10-7 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
pIC50 6.1 (IC50 8x10-7 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
pIC50 <6.0 (IC50 >1x10-6 M) [3]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
PAC1 receptor Hs Agonist Agonist <6.0 pIC50 - 3
⤷ pIC50 <6.0 (IC50 >1x10-6 M) [3]
Description: inhibition of [125I]-PACAP-27 binding to membranes from NIH/3T3 cells stably expressing the recombinant receptor
PAC1 receptor Rn Agonist Agonist <5.0 pIC50 - 1
⤷ pIC50 <5.0 (IC50 >1x10-5 M) [1]
Description: inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor