ivermectin

Ligand id: 2373

Name: ivermectin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 14
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 170.06
Molecular weight 874.51
XLogP 2.84
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Glycine Receptor (All subtypes) Agonist Irreversible agonist 6.4 pEC50 - 4
pEC50 6.4 [4]
nicotinic acetylcholine receptor α7 subunit Allosteric modulator Positive 5.1 pEC50 - 2
pEC50 5.1 (EC50 9x10-6 M) [2]
P2X7 Allosteric modulator Positive - - - 3
[3]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
P2X4 Allosteric modulator Positive ~6.6 pEC50 - 1
pEC50 ~6.6 (EC50 ~2.5x10-7 M) [1]