Ligand id: 2373

Name: ivermectin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 14
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 170.06
Molecular weight 874.51
XLogP 2.84
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
P2X4 Rn Allosteric modulator Positive ~6.6 pEC50 - 1
pEC50 ~6.6 (EC50 ~2.5x10-7 M) [1]
Glycine Receptor (All subtypes) Hs Agonist Irreversible agonist 6.4 pEC50 - 4
pEC50 6.4 [4]
nicotinic acetylcholine receptor α7 subunit Hs Allosteric modulator Positive 5.1 pEC50 - 2
pEC50 5.1 (EC50 9x10-6 M) [2]
P2X7 Hs Allosteric modulator Positive - - - 3