Ligand id: 2373

Name: ivermectin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 14
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 170.06
Molecular weight 874.51
XLogP 2.84
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of parasitic infections (excluding tapeworm), and as a topical treatment for head lice
Mechanism Of Action and Pharmacodynamic Effects
Selective and high affinity modulator of the glutamate-gated chloride ion channel in invertebrate muscle and nerve cells. Binding to this channel causes an increase in cell membrane permeability and hyperpolarisation of the cell leading to paralysis and death of the parasite.
External links