(-)-menthol

Ligand id: 2430

Name: (-)-menthol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 20.23
Molecular weight 156.15
XLogP 3.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPM8 Mm Activator Partial agonist 4.0 – 5.4 pEC50 - 1-2
pEC50 4.0 – 5.4 [1-2]
Voltage: Physiological
TRPM8 Hs Activator - 4.6 pEC50 - 6
pEC50 4.6 (EC50 2.51x10-5 M) inhibited by intracellular Ca2+ [6]
Voltage: -120.0 – 160.0 mV
TRPA1 Hs Activator Partial agonist 4.0 – 4.5 pEC50 - 3,7
pEC50 4.0 – 4.5 (EC50 9.5x10-5 – 2.84x10-5 M) Menthol is also active at the mouse TRPA1, but becomes inhibitory at >100µM [3,7]
Description: Calcium imaging, patch clamp
Conditions: CHO cells expressing human TRPA1
TRPM8 Rn Activator Partial agonist 4.1 – 4.2 pEC50 - 5
pEC50 4.1 – 4.2 [5]
Voltage: -60.0 mV
TRPV3 Mm Activator Activation 1.7 pEC50 - 4
pEC50 1.7 (EC50 1.995x10-2 M) [4]
Voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology and calcium imaging
TRPA1 Mm Gating inhibitor Antagonist 4.2 pIC50 - 4
pIC50 4.2 [4]
Voltage: Physiological
Ligand mentioned in the following text fields