dihydroergocryptine

Ligand id: 282

Name: dihydroergocryptine

Abbreviated name: DHC

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 114.45
Molecular weight 577.33
XLogP 3.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT2B receptor Hs Agonist Biased agonist 7.5 pKi - 3
pKi 7.5 [3]
Description: Biased for β-arrestin signalling.
5-HT7 receptor Mm Antagonist Antagonist 7.0 pKi - 1
pKi 7.0 [1]
5-HT7 receptor Rn Antagonist Antagonist 6.5 pKi - 2
pKi 6.5 [2]
Ligand mentioned in the following text fields