Ligand id: 3342

Name: midazolam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 30.18
Molecular weight 325.08
XLogP 4.95
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRH1 receptor Rn Antagonist Antagonist 5.5 pKi - 1
pKi 5.5 (Ki 3.2x10-6 M) [1]
α1B-adrenoceptor Rn Allosteric modulator Positive 3.7 pKi - 2
pKi 3.7 (Ki 1.83x10-4 M) [2]