midazolam

Ligand id: 3342

Name: midazolam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 30.18
Molecular weight 325.08
XLogP 4.95
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an agent for sedation, anziolysis or amnesia prior to surgical, diagnostic or endoscopic procedures. Also used in the induction of general anaesthesia.
Mechanism Of Action and Pharmacodynamic Effects
Midazolam is a benzodiazepine (BZ) drug binds to the allosteric BZ site on the GABAA channel. This potentiates the inhibitory activity of GABA by increasing the period for which the chloride channel remains open.