chlordiazepoxide

Ligand id: 3370

Name: chlordiazepoxide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 50.46
Molecular weight 299.08
XLogP 3.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In relation to the use of this drug as an anxiolytic, we have been unable to find publicly available, well defined affinity data at the GABAA channel to support this MMOA. Therefore, we have not tagged a primary drug target in this instance.
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRH1 receptor Antagonist Antagonist 4.7 pKi - 2
pKi 4.7 (Ki 2x10-5 M) [2]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRH1 receptor Antagonist Antagonist 4.8 pKi - 1
pKi 4.8 (Ki 1.5x10-5 M) [1]