probenecid

Ligand id: 4357

Name: probenecid

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: probenecid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.06
Molecular weight 285.1
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Sodium/phosphate cotransporter 1 2
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Organic anion transporter 1 Inhibitor Inhibition 4.9 pIC50 - 3
pIC50 4.9 (IC50 1.25x10-5 M) Inhibition of urate transport by human SCL22A6. [3]
OATP1C1 Inhibitor Inhibition - - -
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV2 Activator Activation 4.5 pEC50 - 1
pEC50 4.5 (EC50 3.19x10-5 M) [1]