probenecid

Ligand id: 4357

Name: probenecid

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.06
Molecular weight 285.1
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Competitive inhibition by probenecid has been demonstrated at OAT1, OAT2, OAT3, OAT4, OAT5 [5,7,10,13], and URAT1 [12]. Furthermore, inhibition by probenecid has also been demonstrated at MRP1, MRP2, MRP3, MRP4 and MRP5 [1,4,6,8,11].
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Sodium/phosphate cotransporter 1 3
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPV2 Rn Activator Activation 4.5 pEC50 - 2
pEC50 4.5 (EC50 3.19x10-5 M) [2]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Organic anion transporter 1 Hs Inhibitor Inhibition 4.9 pIC50 - 9
pIC50 4.9 (IC50 1.25x10-5 M) Inhibition of urate transport by human SCL22A6. [9]
OATP1C1 Hs Inhibitor Inhibition - - -