Ligand id: 4357

Name: probenecid

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View more information in the IUPHAR Pharmacology Education Project: probenecid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.06
Molecular weight 285.1
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Bang S, Kim KY, Yoo S, Lee SH, Hwang SW. (2007)
Transient receptor potential V2 expressed in sensory neurons is activated by probenecid.
Neurosci. Lett.425 (2): 120-5. [PMID:17850966]
2. Busch AE, Schuster A, Waldegger S, Wagner CA, Zempel G, Broer S, Biber J, Murer H, Lang F. (1996)
Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions.
Proc. Natl. Acad. Sci. U.S.A.93 (11): 5347-51. [PMID:8643577]
3. Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H. (2003)
Urate transport via human PAH transporter hOAT1 and its gene structure.
Kidney Int.63 (1): 143-55. [PMID:12472777]