Ligand id: 4357

Name: probenecid

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.06
Molecular weight 285.1
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Probenecid is used to reduce serum uric acid levels in patients with chronic gout.
Mechanism Of Action and Pharmacodynamic Effects
Probenecid acts to inhibit the renal excretion of organic anions and in addition, reduces tubular reabsorption of urate. This is likely to occur as a result of inhibition of urate transport by organic anion transporters such as SLC22A6 (OAT1).
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