infliximab

Ligand id: 5004

Name: infliximab

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Bioactivity Comments
Infliximab has been reported to induce an anti-chimeric antibody response in almost 15% of Crohns cisease patients (47 tested) [5]. This indicates that as predicited, humans can mount an immune response to whole murine variable domains, and is the underlying rationale promoting the development of clinical antibodies with variable domains with more human character (i.e. humanised or fully human monoclonal developments).
Selectivity at human ligand targets
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Target Type Action Affinity Units Concentration range (M) Reference
tumour necrosis factor shed form Antibody Binding 8.7 pKd - 4
pKd 8.7 (Kd 1.8x10-9 M) [4]
Description: Binding affinity of antibody cA2 to recombinant human TNFα