enzastaurin

Ligand id: 5693

Name: enzastaurin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 72.16
Molecular weight 515.23
XLogP 5.36
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Enzastaurin exhibits antiangiogenic activity [4] and also induces apoptosis and suppresses proliferation of tumour cells in vitro [3].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
protein kinase C beta Inhibitor Inhibition 7.5 pIC50 - 2
pIC50 7.5 (IC50 3x10-8 M) [2]
protein kinase C alpha Inhibitor Inhibition 6.1 pIC50 - 2
pIC50 6.1 (IC50 8x10-7 M) [2]
protein kinase C delta Inhibitor Inhibition 6.0 pIC50 - 2
pIC50 6.0 (IC50 1x10-6 M) [2]
protein kinase C gamma Inhibitor Inhibition 5.7 pIC50 - 2
pIC50 5.7 (IC50 2x10-6 M) [2]