sunitinib

Ligand id: 5713

Name: sunitinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 77.23
Molecular weight 398.21
XLogP 3.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
KIT proto-oncogene receptor tyrosine kinase Inhibitor Inhibition 9.4 pKd - 2
pKd 9.4 (Kd 3.7x10-10 M) [2]
platelet derived growth factor receptor beta Inhibitor Inhibition 8.1 pKi - 6
pKi 8.1 (Ki 8x10-9 M) [6]
fibroblast growth factor receptor 1 Inhibitor Inhibition 6.1 pKi - 6
pKi 6.1 (Ki 8.3x10-7 M) [6]
ret proto-oncogene Inhibitor Inhibition 8.8 pIC50 - 5
pIC50 8.8 (IC50 1.7x10-9 M) [5]
platelet derived growth factor receptor beta Inhibitor Inhibition 8.2 pIC50 - 5
pIC50 8.2 (IC50 5.7x10-9 M) [5]
fms related tyrosine kinase 3 Inhibitor Inhibition 8.2 pIC50 - 4
pIC50 8.2 (IC50 6.5x10-9 M) [4]
fms related tyrosine kinase 4 Inhibitor Inhibition 8.1 pIC50 - 4
pIC50 8.1 (IC50 8.9x10-9 M) [4]
KIT proto-oncogene receptor tyrosine kinase Inhibitor Inhibition 7.9 pIC50 - 4
pIC50 7.9 (IC50 1.31x10-8 M) [4]
kinase insert domain receptor Inhibitor Inhibition 7.7 pIC50 - 4
pIC50 7.7 (IC50 2.26x10-8 M) [4]
Ligand mentioned in the following text fields