sunitinib

Ligand id: 5713

Name: sunitinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 77.23
Molecular weight 398.21
XLogP 3.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
KIT proto-oncogene receptor tyrosine kinase Hs Inhibitor Inhibition 9.4 pKd - 2
pKd 9.4 (Kd 3.7x10-10 M) [2]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 8.1 pKi - 6
pKi 8.1 (Ki 8x10-9 M) [6]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 6.1 pKi - 6
pKi 6.1 (Ki 8.3x10-7 M) [6]
ret proto-oncogene Hs Inhibitor Inhibition 8.8 pIC50 - 5
pIC50 8.8 (IC50 1.7x10-9 M) [5]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 8.2 pIC50 - 5
pIC50 8.2 (IC50 5.7x10-9 M) [5]
fms related tyrosine kinase 3 Hs Inhibitor Inhibition 8.2 pIC50 - 4
pIC50 8.2 (IC50 6.5x10-9 M) [4]
fms related tyrosine kinase 4 Hs Inhibitor Inhibition 8.1 pIC50 - 4
pIC50 8.1 (IC50 8.9x10-9 M) [4]
KIT proto-oncogene receptor tyrosine kinase Hs Inhibitor Inhibition 7.9 pIC50 - 4
pIC50 7.9 (IC50 1.31x10-8 M) [4]
kinase insert domain receptor Hs Inhibitor Inhibition 7.7 pIC50 - 4
pIC50 7.7 (IC50 2.26x10-8 M) [4]
Ligand mentioned in the following text fields