D4476

Ligand id: 5940

Name: D4476

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 103.12
Molecular weight 398.14
XLogP 3.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
D4476 inhibits phosphorylation of Ser322 and Ser325 of endogenous forkhead box transcription factor O1a (FOXO1a) [4]. Phosphorylation of these residues is required for accelerated nuclear exclusion FOXO1a in response to IGF-1 and insulin.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
casein kinase 1 alpha 1 Inhibitor Inhibition 6.5 pIC50 - 5
pIC50 6.5 (IC50 3x10-7 M) [5]
casein kinase 1 delta Inhibitor Inhibition 6.5 pIC50 - 2
pIC50 6.5 (IC50 3x10-7 M) [2]