Ligand id: 5940

Name: D4476

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 103.12
Molecular weight 398.14
XLogP 3.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
D4476 is a useful chemical tool for identifying physiological substrates of CK1 family serine/threonine protein kinases. In relation to inflammation, there is some experimental evidence to suggest that CK1 inhibitors may be useful for the treatment of inflammatory pain [4].