galantamine

Ligand id: 6693

Name: galantamine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 41.93
Molecular weight 287.15
XLogP 1.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Some activity data maps to other ligands: PubChem CID 908828, PubChem CID 676392 and PubChem CID 3449. Due to the potential poly-pharmacology of this drug we have not tagged a primary drug target.

Galantamine has been shown to be a modulator of the α7 nicotinic acetylcholine receptor [4].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
acetylcholinesterase (Cartwright blood group) Inhibitor Inhibition 6.3 pIC50 - 2
pIC50 6.3 (IC50 5x10-7 M) [2]