Ligand id: 6693

Name: galantamine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 41.93
Molecular weight 287.15
XLogP 1.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Ago Y, Koda K, Takuma K, Matsuda T. (2011)
Pharmacological aspects of the acetylcholinesterase inhibitor galantamine.
J. Pharmacol. Sci., 116 (1): 6-17. [PMID:21498956]
2. Clark JK, Cowley P, Muir AW, Palin R, Pow E, Prosser AB, Taylor R, Zhang MQ. (2002)
Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
Bioorg. Med. Chem. Lett., 12 (18): 2565-8. [PMID:12182861]
3. Prvulovic D, Hampel H, Pantel J. (2010)
Galantamine for Alzheimer's disease.
Expert Opin Drug Metab Toxicol, 6 (3): 345-54. [PMID:20113148]
4. Taly A, Corringer PJ, Guedin D, Lestage P, Changeux JP. (2009)
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.
Nat Rev Drug Discov, 8 (9): 733-50. [PMID:19721446]