levetiracetam

Ligand id: 6826

Name: levetiracetam

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View more information in the IUPHAR Pharmacology Education Project: levetiracetam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 63.4
Molecular weight 170.11
XLogP -0.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at rat transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
synaptic vesicle glycoprotein 2A Inhibitor Inhibition 5.8 pKi - 2
pKi 5.8 (Ki 1.58x10-6 M) [2]
synaptic vesicle glycoprotein 2A Inhibitor Inhibition 6.1 pIC50 - 1
pIC50 6.1 (IC50 7.94x10-7 M) [1]
Description: In vitro inhibitory activity against [3H](2S)-2-[4-(3-azidophenyl)-2-oxopyrrolidin-1-yl]butanamide binding to levetiracetam binding site, in rat brain homogenate