abatacept

Ligand id: 6891

Name: abatacept

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View more information in the IUPHAR Pharmacology Education Project: abatacept

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In a cell based CD80/86 inhibition assay abatacept inhibits IL-2 release with an IC50 of 22.6 nM [2].
Selectivity at other protein targets
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
CD80 Hs Inhibitor Inhibition ~7.9 pKd - 3,5
pKd ~7.9 (Kd ~1.2x10-8 M) [3,5]
Description: Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept.
CD86 Hs Inhibitor Inhibition ~7.9 pKd - 3,5
pKd ~7.9 (Kd ~1.2x10-8 M) [3,5]
Description: Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept.