encenicline

Ligand id: 6926

Name: encenicline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 60.58
Molecular weight 320.08
XLogP 2.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
EVP-6124 binds with high affinity to α7 nAChRs and in rat brain membranes was approximately 300 fold more potent than the natural agonist ACh
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
nicotinic acetylcholine receptor α7 subunit Hs Agonist Partial agonist 8.4 pKi - 1-2
pKi 8.4 (Ki 4.3x10-9 M) [1-2]