encenicline

Ligand id: 6926

Name: encenicline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 60.58
Molecular weight 320.08
XLogP 2.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Encenicline is being assessed in several Phase III clinical trials as a potential treatment for imapired cognition in schizophrenia and in Alzheimer's disease.
Mechanism Of Action and Pharmacodynamic Effects
EVP-6124 is a selective, potent, brain penetrant oral compound that enhances synaptic transmission in the brain and acts as a co-agonist in combination with Acetylcholine (ACh) to enhance cognition [3]