dextromethorphan

Ligand id: 6953

Name: dextromethorphan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 12.47
Molecular weight 271.19
XLogP 4.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have identified binding affinity data for the sigma opioid receptor, SIGMAR1 [2], but have been unable to find publicly available data providing the same for the σ2 receptor. We have not tagged a primary target for this drug.
Selectivity at human ion channels
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Target Type Action Affinity Units Concentration range (M) Reference
GluN2C Channel blocker - 6.3 pIC50 - 1
pIC50 6.3 (IC50 4.66x10-7 M) [1]
Description: Measured vs. exogenously expressed zeta1/epsilon3 (GRIN1/GRIN2C) subunits, at pH 6.9
Selectivity at human other protein targets
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
sigma non-opioid intracellular receptor 1 Agonist Agonist 6.3 pKi - 2
pKi 6.3 (Ki 5.21x10-7 M) [2]
Description: Sigma receptor cloned from Jurkat cells, identified as SIGMAR1.