aminoglutethimide

Ligand id: 7054

Name: aminoglutethimide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 72.19
Molecular weight 232.12
XLogP 1.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Low doses of aminoglutethimide inhibit only CYP19A1 function, but at higher doses both enzymes are inhibited.
Selectivity at hamster enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CYP11A1 Inhibitor Inhibition 4.5 pIC50 - 1
pIC50 4.5 (IC50 3x10-5 M) [1]
Description: Measuring inhibition of progesterone synthesis in hamster ovarian slices as an indicatior of CYP11A1 activity.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CYP19A1 Inhibitor Inhibition - - - 2
[2]