Ligand id: 7054

Name: aminoglutethimide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 72.19
Molecular weight 232.12
XLogP 1.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A. (1991)
Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.
J. Med. Chem., 34 (2): 725-36. [PMID:1825337]
2. Payne EJ, Ingley E, Dick IM, Wilson SG, Bond CS, Prince RL. (2009)
In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors.
J. Clin. Endocrinol. Metab., 94 (8): 2998-3002. [PMID:19470632]