Ligand id: 7054

Name: aminoglutethimide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 72.19
Molecular weight 232.12
XLogP 1.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat Cushing's syndrome and metastatic breast and prostate cancers.
Mechanism Of Action and Pharmacodynamic Effects
By inhibiting CYP19A1 and CYP11A1, aminoglutethimide blocks the production of steroids derived from cholesterol.