fluticasone propionate

Ligand id: 7080

Name: fluticasone propionate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 105.97
Molecular weight 500.18
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Glucocorticoid receptor Hs Agonist Agonist 8.1 pEC50 - 2
pEC50 8.1 (EC50 9x10-9 M) [2]
Progesterone receptor Hs Agonist Agonist 7.7 pEC50 - 2
pEC50 7.7 (EC50 2.1x10-8 M) [2]
Mineralocorticoid receptor Hs Agonist Agonist 6.8 pEC50 - 2
pEC50 6.8 (EC50 1.49x10-7 M) [2]
Glucocorticoid receptor Hs Agonist Agonist 9.3 pIC50 - 1
pIC50 9.3 (IC50 5x10-10 M) [1]
Description: Inhibition of [3H]dexamethasone binding to recombinant human glucocorticoid receptor ecpressed in Tni cells.