phenoxybenzamine

Ligand id: 7268

Name: phenoxybenzamine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 12.47
Molecular weight 303.14
XLogP 6.55
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have curated affinity data for the human α2B-AR, but note that this is not a selective antagonist, so will have antagonist action at other α-adrenoceptors.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α2B-adrenoceptor Antagonist Antagonist 8.5 pKi - 1
pKi 8.5 (Ki 3.5x10-9 M) [1]