phenoxybenzamine

Ligand id: 7268

Name: phenoxybenzamine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: phenoxybenzamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 12.47
Molecular weight 303.14
XLogP 6.55
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
We have curated affinity data for the human α2B-AR, but note that this is not a selective antagonist, so will have antagonist action at other α-adrenoceptors.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
α2B-adrenoceptor Hs Antagonist Antagonist 8.5 pKi - 1
pKi 8.5 (Ki 3.5x10-9 M) [1]