Ligand id: 7268

Name: phenoxybenzamine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: phenoxybenzamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 12.47
Molecular weight 303.14
XLogP 6.55
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension and sweating in pheochromocytoma patients.
Mechanism Of Action and Pharmacodynamic Effects
Phenoxybenzamine is an antagonist of α-adrenoceptors. This action causes vasodilation and reduces blood pressure.
External links